In almost all cases 'Yes'. Indigo is known to work with most USB serial port devices and Bluetooth serial port devices. There are a few devices that have limited drivers that don't adhere to the standard serial interface API and Indigo may not function correctly with these particular hardware devices.
With the release of Indigo Version 3 there is an improved serial communication library included that works with 99.9% of the serial port devices that we have encountered.
Please download the evaluation version of Indigo to try it out for yourself:
>> Download Indigo Evaluation